Alzheimer’s Disease Genetic Mutations: Mini Review

Identification of Genetic Polymorphism Interactions in Sporadic Alzheimer’s Disease Using Logic Regression

Objectives: Genetic polymorphism interactions are among the important factors in affliction with complex diseases like Alzheimer’s disease. The important goal of genetic association studies is to identify a combination of polymorphisms and measure their importance in increasing the risk of occurrence of such diseases. In this study, feature selection approach of logic regression was used to ide...

Genetic Mutations that Cause Coronary Artery Disease

Genetic risk factors of Alzheimer’s disease and cell-to-cell transmission of Tau

In Alzheimer’s disease (AD), loss of neurons and synapses parallels the formation of neurofibrillary tangles, protein aggregates mainly composed of hyperphosphorylated and aggregated Tau protein. Tau is mostly a cytosolic protein but can also be secreted by neurons. Cell-to-cell transfer of misfolded Tau protein plays a key role in the spread of neurofibrillary pathology between brain regions i...

The role of genetics in alzheimer’s disease

Alzheimer's disease is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells die. Alzheimer's disease is the most common cause of dementia and causes a decrease in thinking skills and social behaviors. Alzheimer's disease is more common in people over 65 years old. The risk of developing Alzheimer's disease and other types of dementia increases with age,...

Comparing the Diagnostic Value of Four Dementia Tests in the Amnestic and Healthy Elderly

Objective: This study aimed to compare the diagnostic value of 4 questionnaires for the diagnosis of neurocognitive disorders (NCDs) in the elderly. Methodology: In this project, people older than 60 years who lived in Tehran were investigated. A total of 99 literate persons were enrolled in the study, and 4 questionnaires of functional assessment staging tool (FAST), abbreviated mental test s...